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2020.08.25

News

PURITY DEGREE OF SHINKOWA’S NMN

Shinkowa is proud to present NMN with a purity of 99% at least, whose safety has been confirmed both in humans and rodents. Such high-quality NMN can only be offered by two companies in the world, including us.

The Institute for Research on Productive Aging (IRPA) has carried out two different purity tests (LC-UV (1) and NMR (2)) on four NMN samples from as many companies, including ours, and the only NMN that has obtained high purity results of over 99% in both tests is Shinkowa Pharmaceutical’s NMN. This suggests that the NMN from the other three companies may contain a great deal of impurities, such as water or heavy metals.
(1): High performance liquid chromatography- UV absorption spectroscopy
(2): Nuclear magnetic resonance spectroscopy

Our products were also selected for a clinical study on NMN conducted by the University of Washington with a grant from the US Department of Defense for their superiority in terms of purity and stability over other companies’ products.

◆COMPARISON OF NMN PURITY◆

(3) Self-Affirmed GRAS: The US GRAS system (Generally Recognized as Safe), implemented by the US Food and Drug Administration (FDA), is a safety evaluation carried out by independent toxicity experts. The so-called Self-Affirmed GRAS, a kind of self-certification, is not officially recognized by FDA.

An NMN with low purity obviously means it contains more impurities.
It is not known as yet what kind of adverse effects can result from the ingest of NMN with a large amount of impurities.
Please be aware that you can find on the market products which claim to contain NMN, but whose purity degree (not declared) is low and its safety is not proven.

◆ Institute for Research on Productive Aging (IRPA)◆

https://www.irpa.ne.jp/

 

■SAFETY, EVALUATION, AND OTHER TESTS BY SHINKOWA PHARMACEUTICAL
・Purity: 99% at least
・Acceleration deterioration test: Maintains purity of at least 99% after 3 months at 40℃

RESEARCH BY SHINKOWA PHARMACEUTICAL CO., LTD.

■ First time (Japanese Food Analysis Center: completed on August 17, 2015)
・Acute oral toxicity test: no abnormalities or deaths
・Reverse mutation test: negative
・Primary skin irritation test: non-irritant
・Eye irritation test: non-irritant

■Second time (DRC Corporation: completed on November 23, 2015)
”Food containing resveratrol and nicotinamide mononucleotide.
Examination of lipid improvement effect by intake of composition”
No safety problems /detailed results not disclosed (human subjects)

■Third time (Graduate School of Biomedical & Health Sciences, Hiroshima University: completed on March 31, 2019)
“Evaluation of the effects of long-term intake of nicotinamide mononucleotide (NMN)”
https://upload.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000029616
No safety problems /detailed results not disclosed (human subjects)

■Fourth time (Japanese Food Analysis Center: completed on July 7, 2018)
・Acute oral toxicity test: no abnormalities or deaths
・Reverse mutation test: negative
・Primary skin irritation test: non-irritant
・Eye irritation test: non-irritant

Shinkowa Pharmaceutical’s products contain NMN with the highest purity and stability only.
In addition to the tests above, we have conducted and completed other safety and evaluation tests and have confirmed its safety every time.

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