Shinkowa Pharmaceutical, Co. Ltd. (Main office: Tokyo, Japan; CEO: Megumi Tanaka) was the first company in the world to commercialize supplements and cosmetics with β- nicotinamide mononucleotide (NMN), a substance that is generally considered to contribute to healthy lifespan, and guarantees at least an amazing 99% of purity. We conducted the world’s first NMN clinical research on humans and have established a reputation as pioneers in the field of NMN bio-ventures by launching steadily a range of products based on science. We take care of them all the way from the research phase to the commercialization of the final product. What’s more, Shinkowa is proud to present NMN with high purity and stability, whose safety has been confirmed both in humans and rodents. Such NMN can only be offered by two companies in the world, including us. Our goal is contributing to society by improving our quality of life based on science.
The new NMN TRANSPORT WATER will be available from August 25, and you can buy it with a special 15% off price of 11,016 yen (tax included) until September 8. You can find it on the Mirai Lab Online Store, as well as on the main platforms: Amazon, Yahoo! Shopping and Rakuten Market.
■ Product overview
・Product name: NMN TRANSPORT WATER
・Contents: 120 g (4.0 g x 30 sticks)
・Price: 12,960 yen (tax included)
・Country of origin: Japan
・Nutrition facts: energy 14.96kcal /protein 0.0024g /lipid 0g/carbohydrates 3.71g/ table salt equivalent 0.1556g (per 1 stick: 4 g)
・Raw materials: sugar (made in Japan), glucose, table salt/ citric acid, flavor, calcium silicate, sweetener (acesulfame potassium)
・How to take: take 1 stick per day with water or your favorite infusion.
THIS PRODUCT DOES NOT CONTAIN NMN.
■You can purchase our products on the following stores.
●Mirai Lab Official Online Store
ABOUT SHINKOWA PHARMACEUTICAL’S NMN
Our NMN is highly pure and highly stable, and its safety has been confirmed in both humans and rodents. Only two companies in the world can offer NMN like this, and we are one of them.
In addition, two different purity tests (LC-UV (1) and NMR (2)) were carried out on NMN samples from 4 different companies, including ours, and the only NMN that got results of at least 99% purity on both tests was our NMN.
These results indicate that the NMN from the other three companies may contain more impurities, such as water or heavy metals.
(1): High performance liquid chromatography- UV absorption spectroscopy
(2): Nuclear magnetic resonance spectroscopy
More about Shinkowa Pharmaceutical’s NMN- purity and impurities (purity comparison table) on our web.
– We have confirmed the existence of malicious sites that copy and paste pictures and explanatory texts directly from our own website and offer our products illegally. To certify that the products you receive are genuine, you will start finding on our products authentication holograms from July 15, 2020. While we would like to extend this security measure to all our products as soon as possible, please note that some of the products acquired through our Mirai Lab and Mirai Dakara stores on Amazon will not display the holograms yet. We would like to thank you in advance for your understanding.
・Please note that there are products on the market that do not contain NMN, even though “NMN” is displayed on their labels, and also products whose safety has not been confirmed.
■ What is NMN (β-nicotinamide mononucleotide)?
NMN (β-nicotinamide mononucleotide) is a safe substance made from vitamin B3 in the cells of living organisms, and it is present in all creatures. It is found in relatively high amount in foods such as broccoli and edamame beans, but we cannot replenish our NMN body stock with our daily ingest of food. More and more pieces of evidence suggest health improvement by taking purer NMN. For example, it has been reported improvement on cases of geriatric obesity, diabetes, fatty liver, hyperlipidemia, decreased metabolic muscle capacity, decreased bone density, decreased activity, and many others.
While research is ongoing around the world to find out more about its mechanisms, it has been discovered so far that NMN is converted to another substance called NAD＋and acts on the life support center of the hypothalamus, which in turn acts on skeletal muscle, viscera, cells, mitochondria, blood vessels, nerves and response proteins (signal substances) among others, all essential for sustaining life.
Taking NAD＋directly will not cause the same effects as taking NMN. The reason is that when NAD＋is ingested, most of it is broken up in the digestive tract. In addition, NAD＋does not pass through the brain-blood barrier or enter the cells easily. Direct administration of NAD＋ into blood vessels may cause abnormal glucose metabolism, a reaction similar to diabetes. For all these reasons, it is important to take NMN, not NAD＋.
Compared to NAD＋, the absorption rate of NMN into the cells is considered higher, so it should be extremely suitable for intracellular NAD+ deficiency.
In the human epidermis, regeneration (the physiological process of discarding old, deteriorated cells and replacing them with new cells) happens continuously and proper gene expression in the cells is essential for this process. As NMN enters the cells and is converted to NAD+, it is expected to eliminate problems caused by aging: the lack of NAD+, the abnormal gene expression and the disruption of physiological processes, such as cell regeneration, among others.
■RESEARCH ACHIEVEMENTS OF SHINKOWA PHARMACEUTICAL
●In November 2019, Shinkowa concluded an agreement to donate the NMN that would be used by the University of Washington (St. Louis, Missouri, USA) in a clinical study entitled “Effect of NMN Supplementation on Organ System Biology” that would be conducted at the University premises after having received a grant from the U.S. Department of Defense.
For more details: https://shinkowapharma.com/en/information/458/
●In July 2019, National University of Yamaguchi, Veterinary Department (Prof. Toru Kimura, Biofunctional Sciences, Experimental Zoology), taking dogs as subjects, conducted the study “Longevity and Anti-aging Effects of NMN Administration on Dogs: Observation of Improvement of Blood Components and Intestinal Flora Associated with Activation of Longevity Genes.” We are currently making preparations for a joint research in order to develop the results obtained from this research.
● Life Science Research Program
In November 2018, we concluded an agreement with the non-profit organization The Systems Biology Institute (CEO: Dr. Hiroaki Kitano) to carry out research that aims to elucidate the mechanisms of action of NMN. This study is called ” Elucidation of Intracellular Mechanism of NMN by Multi-Omics Analysis”.
Click here for details: https://shinkowapharma.com/en/information/202/
● We have conducted the world’s first clinical research to analyze the long-term oral intake of NMN (24 weeks) with the Graduate School of Medical and Dental Health Sciences, National University of Hiroshima. In the final report, we confirmed an increase in the expression level of sirtuin 1 (longevity gene or antiaging gene) and many different growth hormones. Through the increase of expression level of sirtuin 1, we can expect suppression and complete recovery from various age-derived health problems, such as lifestyle-related diseases, cancer, dementia and other chronic diseases. As previously mentioned, we confirmed the increase of various growth hormones, but the increase of melatonin was especially remarkable. Melatonin is deeply involved in sleeping, and many consider that quality sleep is in turn involved in cancer suppression.
●Established our own NMN laboratory “Life Science Lab”
In June 2019, we opened and started operating our in-house research laboratory in Nihonbashi, Tokyo, Japan, with the aim to further increase the scientific basis of NMN. Currently, we are conducting research in our Life Science Lab with the goal of demonstrating scientifically the effects of NMN, a safe organic substance, to strengthen immunity and help prevent and treat infectious diseases, as one of the measures taken against infectious diseases, including the COVID-19 (new coronavirus).
For more details: https://shinkowapharma.com/en/information/520/
In addition to the projects stated above, we are engaged in other activities, including research in our in-house laboratory and joint research with Japanese universities.
Shinkowa Pharmaceutical Co., Ltd.